张岩 副研究员

M.D. Ph.D.

信号转导研究室Co-PI

联系电话: 010-6275-3417

E-mail: zhangyan9876@pku.edu.cn

通讯地址：缅甸腾龙国际官网市海淀区颐和园路5号，缅甸腾龙国际官网新生命科学大楼131信箱 100871

 

2003年毕业于缅甸腾龙国际官网医学部，获医学学士学位；2008年获缅甸腾龙国际官网生理学博士学位；2005-2007年在美国新泽西医科和牙科大学从事博士后研究；2008-2010年于缅甸腾龙国际官网腾龙娱乐app官网下载研究所进行博士后研究；2010年至今在缅甸腾龙国际官网腾龙娱乐app官网下载研究所信号转导研究室，获聘副研究员。曾获国际心脏研究会（ISHR）第二十届世界大会Richard J Bing青年科学家奖决赛奖（2010）、中国生理学会张锡钧基金会第八届全国青年优秀生理学论文奖二等奖（2011）。

主要研究兴趣：心肌细胞损伤保护的信号机制研究；代谢综合征及其心血管并发症的发生机制及其预防治疗策略研究。

代表论文：

1. Song RS, Peng W, Zhang Y（张岩）*, Lv F, Wu HK, Guo J, Cao Y, Pi Y, Zhang X, Jin L, Zhang M, Jiang P, Liu F, Meng S, Zhang X, Jiang P, Cao CM, Xiao RP. Central Role of E3 Ubiquitin Ligase MG53 in Insulin Resistance and Metabolic Disorders. Nature, 2012 (Accepted) (* 共同第一作者).

2. Zhang Y（张岩）, Zhang T, Cao CM, Xiao RP. mTOR: Good, Bad, or Ugly? Cardiovasc Res, 2012; 10.1093/cvr/cvs201.

3. Weisleder N, Takizawa N, Lin P, Wang X, Cao CM, Zhang Y（张岩）, Tan T, Ferrante C, Zhu H, Chen PJ, Yan R, Sterling M, Zhao X, Hwang M, Takeshima M, Cai C, Cheng H, Takeshima H, Xiao RP, Ma J. Recombinant MG53 Protein Modulates Therapeutic Cell Membrane Repair in Treatment of Muscular Dystrophy. Sci Transl Med, 2012; 4: 139ra85.

4. Zhang Y（张岩）, Lv FX, Jin L, Peng W, Song RS, Ma J, Cao CM, Xiao RP. MG53 Participates in Ischemic Postconditioning through the RISK Signaling Pathway. Cardiovasc Res, 2011, 91, 108-115

5. Zhang XQ, Zhang RL, Raab S, Zheng W, Wang J, Liu N, Zhu TG, Xue LF, Song ZT, Mao JM, Li KT, Zhang HL, Zhang Y（张岩）, Han C, Ding Y, Wang H, Hou N, Liu YL, Shang SJ, Li CY, Sebokova E, Cheng HP, Huang PL. Rhesus Macaques Develop Metabolic Syndrome With Reversible Vascular Dysfunction Responsive to Pioglitazone. Circulation, 2011, 124, 77-86.

6. Zhang Y（张岩）, Cao CM, Xiao RP. Kinase Activity-Independent Anchoring Function of Protein Kinase C?. Am J Physiol-Cell Ph, 2010, 299: C733-735

7. Cao CM, Zhang Y（张岩）*, Weisleder N, Ferrante C, Wang X, Lv F, Zhang Y, Song R, Hwang M, Jin L, Guo J, Peng W, Li G, Nishi M, Takeshima H, Ma J, Xiao RP. MG53 Constitutes a Primary Determinant of Cardiac Ischemic Preconditioning. Circulation, 2010; 121: 2565-2574 (with editorial: 2547-2549; Faculty of 1000 Biology: http://www.f1000biology.com/article/id/3849956) (* 共同第一作者).

8. Peng W, Zhang Y（张岩）*, Zheng M, Cheng H, Zhu W, Cao CM, Xiao RP. Cardioprotection by CaMKII-δB is mediated by phosphorylation of HSF1 and subsequent expression of inducible HSP70. Circ Res, 2009; 106: 102-110. (*共同第一作者).

9. Li CY, Zhang Y, Wang Z, Zhang Y（张岩）, Cao CM, Zhang PW, Lu SJ, Li XM, Yu Q, Zheng X, Du Q, Uhl GR, Liu QR, Wei L. A Human-Specific De Novo Protein-Coding Gene Associated with Human Brain Functions. PLoS Comput Biol. 2010; 6: e1000734.

10. Peng W, Zhang Y（张岩）, Cao CM, Xiao RP. AMPK and TNF-? at the crossroads of cell death and survival in ischemic heart. Cardiovasc Res, 2009; 84:1-3.

11. He X, Liu Y, Zhang Y（张岩）, Zhang R, and Yang B. Hemodynamic characteristics of chronic congestive heart failure model in awake Beagle dogs. Zhong Nan Da Xue Xue Bao Yi Xue Bao, 2009; 34: 487-491.

12. Shen YT, Depre C, Yan L, Park JY, Tian B, Jain K, Chen L, Zhang Y（张岩）, Kudej RK, Zhao X, Sadoshima J, Vatner DE,. Vatner SF. Repetitive Ischemia by Coronary Stenosis Induces a Novel Window of Ischemic Preconditioning. Circulation, 2008; 118: 1961-1969.