王显花 副研究员

Ph.D.

钙信号研究室Co-PI

联系电话：010-6275-4605

E-mail：xianhua@pku.edu.cn

通讯地址：缅甸腾龙国际官网英杰交流中心339室 100871

1996-2000年就读于缅甸腾龙国际官网生命科学学院生物化学与分子生物学专业，获理学学士学位；2000-2005年于缅甸腾龙国际官网生命科学学院硕博连读，获理学博士学位；2005-2007年在缅甸腾龙国际官网腾龙娱乐app官网下载研究所钙信号转导实验室进行博士后期间的研究；2009-2010年在美国健康卫生研究院（NIH）老年研究所进行合作研究；2007-今就职于缅甸腾龙国际官网分子研究研究所。2010年获得美国健康卫生研究院FARE奖。

主要研究兴趣：1）线粒体ROS信号，尤其是量子化“超氧炫”信号的生理功能和产生机制；2）线粒体膜通透性孔道（mPTP）分子组份的鉴定。

代表论文：

1. Xie W.J., Brochet D.X.P., Wei S., Wang X.H., Cheng H.P., Deciphering ryanodine receptor array operation in cardiac myocytes. The Journal of General Physiology, 2010, 136: 129.

2. Wang X.H.*, Xie W.J., Zhang Y., Lin P.H., Han L., Han P.D., Wang Y.R., Chen Z., Ji G.J., Zheng M., Weisleder N., Xiao R.P., Takeshima H., Ma J.J. *, Cheng H.P., Cardioprotection of ischemia-reperfusion injury by cholesterol-dependent MG53-mediated membrane repair. Circulation Research, 2010，107: 76 . *, co-corresponding author.

3. Cao C.M., Zhang Y., Weisleder N., Ferrante C., Wang X.H., Lv F.X., Zhang Y., Song R.S., Hwang M.S., Jin L., Guo J.J., Peng W., Li G., Nishi M., Takeshima H., Ma J.J., Xiao R.P., MG53 constitutes a primary determinant of cardiac ischemic preconditioning. Circulation, 2010， 121: 2565.

4. Wei C.L., Wang X.H., Chen M., Ou-Yang K.F., Zheng M., Cheng H.P., Flickering calcium microdomains signal turning of migrating cells. Canadian Journal of Biochemistry and Physiology, 2010, 88: 105.

5. Wei C.L., Wang X.H., Ou-Yang K.F., Chen M., Song L.-S., Cheng H.P., Calcium flickers steer cell migration. Nature, 2009, 457:901.

6. Wang W., Fang H.Q., Groom L.D., Cheng A.W., Zhang W.R., Liu J., Wang X.H., Li K.T., Han P.D., Zheng M., Yin J.H., Wang W.D., Mattson M.P., Kao J.P.Y., Lakatta1 E.G., Sheu S.S., Ou-Yang K.F., Chen J., Dirksen R.T., Cheng H.P., Superoxide flashes in single mitochondria. Cell, 2008, 134: 279.

7. Xiao B.L., Tian X.X., Xie W.J., Jones P. P., Cai S.T., Wang X.H., Jiang D.W., Kong H.H., Zhang L., Chen K.Y., Walsh M.P., Cheng H.P., Wayne Chen S.R., Functional consequence of PKA-dependent phosphorylation of the cardiac ryanodine receptor: sensitization of store-overload-induced Ca2+ release. The Journal of Biological Chemistry. 2007, 282: 30256.

8. Yao L.J., Wang G., Ou-Yang K.F., Wei C.L., Wang X.H., Wang S.R., Yao W., Huang H.P., Luo J.H., Wu C.H., Liu J., Zhou Z., Cheng H.P., Ca2+ sparks and Ca2+ glows in superior cervical ganglion neurons. Acta Pharmacologica Sinica. 2006, 27(7):848.

9. Wang X.H., Qin Y., Hu M.H., Xie Y., Dendritic cells pulsed with gp96-peptide complexes derived from human hepatocellular carcinoma (HCC) induce specific cytotoxic T lymphocytes. Cancer Immunology Immunotherapy. 2005，54(10): 971.

10. Wang X.H., Qin Y., Hu M.H., Xie Y., Dendritic cells pulsed with hsp70-peptide complexes derived from human hepatocellular carcinoma induce specific anti-tumor immune responses. World Journal of Gastroenterology. 2005，11（36）：5614.

11. Qin Y., Wang X.H., Cui H.L., Cheung Y.K., Hu M.H., Zhu S.G., Xie Y., Human papillomavirus (HPV) type16 E7 peptide38-61 linked with an immunoglobulin G fragment provides protective immunity in mice. Gynecologic Oncology. 2005，96：475.